منابع مشابه
Macrolides in dermatology
Erythromycin was the first macolide discovered in 1952. In 1990s new macrolides including clarithromycin, azithromycin, and dirithromycin were introduced to the market. We provide a review of their structure, pharmacokinetics, mechanisms of action, and indications in dermatology.
متن کاملFetal safety of macrolides.
Macrolide antibiotics are largely used in pregnancy for different bacterial infections. Their fetal safety has been studied by several groups, yielding opposing results. In particular, there have been studies claiming an association between macrolides and cardiovascular malformations. Exposure in early infancy has been associated with pyloric stenosis and intussusception. This has led to an avo...
متن کاملMethacholine and Macrolides
study are relevant, I believe that the design of the study was not adequate to answer these questions. First, all patients were on NM for w3 months and one patient even for 70 months, whereas they trained only for 1 day on FFM. In our centre (Dept of Pulmonary Diseases/ Home mechanical ventilation, University Hospital Groningen, Groningen, The Netherlands), patients routinely need more time (y7...
متن کاملIntracellular metabolism and bioactivity of quercetin and its in vivo metabolites.
Understanding the cellular effects of flavonoid metabolites is important for predicting which dietary flavonoids might be most beneficial in vivo. Here we investigate the bioactivity in dermal fibroblasts of the major reported in vivo metabolites of quercetin, i.e. 3'-O-methyl quercetin, 4'-O-methyl quercetin and quercetin 7-O-beta-D-glucuronide, relative to that of quercetin, in terms of their...
متن کاملChemobiosynthesis of new antimalarial macrolides.
We have synthesized new derivatives of the macrolide antibiotics erythromycin and azithromycin. Novel deoxysugar moieties were attached to these standard antibiotics by biotransformation using a heterologous host. The resulting compounds were tested against several standard laboratory and clinically isolated bacterial strains. In addition, they were also tested in vitro against standard and dru...
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ژورنال
عنوان ژورنال: Clinical Microbiology and Infection
سال: 1996
ISSN: 1198-743X
DOI: 10.1111/j.1469-0691.1996.tb00588.x